Reactive Aldehydes and Neurodegenerative Disorders
نویسندگان
چکیده
Nörodejeneratif hastalıklara olan ilgi özellikle son birkaç yılda belirgin bir şekilde artma göstermektedir. Fakat bu artan özel ilgiye rağmen, Alzheimer hastalığı (AH), Parkinson hastalığı (PD), multiple skleroz (MS) ve amiyotrofik lateral skleroz (ALS) gibi norodejeneratif hastalıkların patolojik mekanizmaları kesin olarak aydınlatılamamıştır. Endojen reaktif aldehitlerin (malondialdehit [MDA], 4-hydroxynonenal[HNE], acrolein, 3-aminopropanal [3-AP], formaldehit ve methylglyoxal) bu hastalıklardaki rolü için giderek artan kanıtlar vardır. Bu reaktif aldehitlerin çok çeşitli kaynaklar tarafından üretildiği ve hem in vitro hem de in vivo olarak çok sayıda nörotoksik ve gliotoksic özelliklere sahip olduğu gösterilmiştir. Bu makalede reaktif aldehitler ve bunların nörodejeneratif hastalıkların altında yatan patolojik süreçler ile ilgili bağlantılarını oluşturan kanıtlar ele tartışılmıştır.
منابع مشابه
4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies.
SIGNIFICANCE Among different forms of oxidative stress, lipid peroxidation comprises the interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the formation of highly reactive electrophilic aldehydes. Among these, the most abundant aldehydes are 4-hydroxy-2-nonenal (HNE) and malondialdehyde, while acrolein is the most reactive. HNE is considered a robust marker o...
متن کاملNeurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines.
The concept of "oxidative stress" has become a mainstay in the field of neurodegeneration but has failed to differentiate critical events from epiphenomena and sequalae. Furthermore, the translation of current concepts of neurodegenerative mechanisms into effective therapeutics for neurodegenerative diseases has been meager and disappointing. A corollary of current concepts of "oxidative stress...
متن کاملNpgRJ_NCHEMBIO_782 1..5
Oxidative stress, inflammation and a-synuclein overexpression1 confer risk for development of a-synucleinopathies— neurodegenerative diseases that include Parkinson disease and Lewy body dementia2. Dopaminergic neurons undergo degeneration in these diseases and are particularly susceptible to oxidative stress because dopamine metabolism itself creates reactive oxygen species3. Intraneuronal dep...
متن کاملThe Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.
Aldehydes-induced toxicity has been implicated in many neurodegenerative diseases. Exposure to reactive aldehydes from (1) alcohol and food metabolism; (2) environmental pollutants, including car, factory exhausts, smog, pesticides, herbicides; (3) metabolism of neurotransmitters, amino acids and (4) lipid peroxidation of biological membrane from excessive ROS, all contribute to 'aldehydic load...
متن کاملMitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products
In several human diseases, such as cancer and neurodegenerative diseases, the levels of reactive oxygen species (ROS), produced mainly by mitochondrial oxidative phosphorylation, is increased. In cancer cells, the increase of ROS production has been associated with mtDNA mutations that, in turn, seem to be functional in the alterations of the bioenergetics and the biosynthetic state of cancer c...
متن کاملFree radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress.
Aging is one of the unique features in all organisms. The impaired functional capacity of many systems characterizes aging. When such impairments occur in the brain, the susceptibility to neurodegenerative diseases amplifies considerably. The free radical theory of aging posits that the functional impairments in brains are due to the attack on critical cellular components by free radicals, reac...
متن کامل